OSCE PREFINAL EXAMINATION

Date :1/12/ 2023

Case blog:

http://vasavipakker.blogspot.com/2023/11/female-with-break-bone-fever.html

25 yr old female housewife by occupation  resident of nalgonda came to general medicine OPD with 

Chief complaints:-

Body pains since 6 days

Fever since 3 days

On examination:

Hess test positive .

NS 1 antigen detected

PROVISIONAL DIAGNOSIS:  Dengue fever

LINK: http://vasavipakker.blogspot.com/2023/11/female-with-break-bone-fever.html

WHAT ARE THE NEWER MODALITIES FOR TREATING DENGUE??

DOXYCYCLINE
link:https://journals.lww.com/jfmpc/fulltext/2022/06000/effect_of_doxycycline_and_doxycycline_with_carica.161.aspx#:~:text=The%20study%20results%20indicate%20that,and%20to%20minimize%20hospital%20stay
Doxycycline is a derivative of tetracycline that possesses broad antimicrobial and antiinflammatory activities. Further, antiviral activity of doxycycline has been reported against retroviruses, and a significant reduction in retrovirus titre was observed after incubation of infected cells with doxycycline.  studies have shown that doxycycline inhibits dengue virus plaque formation by disrupting the conformational changes in the viral envelope that are necessary for virus entry. studies also found the antidengue properties of doxycycline against all four dengue virus serotypes in vitro. doxycycline interfered with dengue virus protease and impaired virus binding to the host cells, leading to reduced viral replication in infected cells.

JNJ1802 Antiviral drug against dengue. Completed phase 2 trials.

HOW DOES INPUT AND OUTPUT CHART HELPS IN MANAGEMENT OF DENGUE

Ensures accurate record keeping
Prevents circulatory overload 
Prevents dehydration
Aids in analyzing trends in fluid status
Contributes to accurate assessment record


HAEMATOCRIT IN DENGUE MANAGEMENT

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